Thursday September 30

07h30
Welcoming coffee

08.00
Welcome address
Jean-Olivier Defraigne, Liège, Belgium
Helena Kuivaniemi, Danville, USA


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GENETICS AND GENOMICS OF TAAD AND AAA
Moderators: Helena Kuivaniemi & Gerard Tromp

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08h10 Genetic basis of syndromic TAAD
Bart Loeys, Gent, Belgium


08h30  Genetic basis of thoracic aortic aneurysms and aortic dissections: gene-based management
Dianna Milewicz, Houston, Texas, USA

08h50 Gene expression profiles associated with TAA in patients with bicuspid aortic valve
Per Eriksson, Stockholm, Sweden

09h10  3’-UTR and coding-sequence miR-29 binding sites repress elastin gene expression in postnatal aortic development
Peter N. Robinson, Berlin, Germany

pdf

09h30  Short presentations

The Role of Complement Cascade in Abdominal Aortic Aneurysms
Hinterseher Irene, Danville, United States
journal

Genotype-phenotype correlation in 104 patients with vascular Ehlers-Danlos syndrome in a French cohort: Evidence for a mild form of the disease.
Bal Laurence, Paris, France
journal

High resolution melting analysis to detect rare genetic variants associated with abdominal aortic aneurysm
Harrison Seamus, London, United Kingdom
journalpdf


09h50  Coffee break

10h20  Genome wide study on AAA
Solveig Gretarsdottir, Reykjavik, Iceland

10h40  The aneurysm consortium AAA GWAS
Matthew Bown, Leicester, United Kingdom

11h00  Assessing the potential value of tissue and circulating markers of abdominal aortic aneurysm
Jonathan Golledge, Townsville, Australia

11h20  Genetic and genomic studies of AAA
David Carey, Pennsylvania, USA
pdf

11h40  Distinct defects in collagen micro architecture underlie vessel wall failure in AAA and aneurysms in Marfan syndrome
Jan Lindeman, Leiden, The Netherlands
pdf

12h00  Differential regulation of Lamin A/C in AAA - a putative new target for therapy
Gillian W Cockerill, London, United Kingdom
pdf

12h20  Short presentations

Relationship between osteopontin plasma levels and ascending  aortic dilation
Bevilacqua Stefano, Massa, Italy
journal

Altered microRNAs in bicuspid aortic valve
Mohamed Salaheldien Ali, Luebeck, Germany
journalpdf


12h30  Lunch

13h30  Industry symposium
CARDOZ
A new medical approach to treat AAA
Moderators: Jesper Swedenborg

13h30  Introduction Jesper Swedenborg
13h35  Pharmacological approaches in AAA Johan Raud
13h45  The role ofmast cells inAAA Jesper Swedenborg
14h05  A clinical study of amast cell inhibitor in AAA Carl-JohanDalsgaard
14h15  Questions & closing remarks Jesper Swedenborg



13h30 Posters presentations
Moderators: Betty Nusgens & Per Eriksson

Cystatin C correlates with short-term abdominal aortic aneurysm growth
Melina Vega de Céniga, Galdakao-Usansolo (Bizkaia), Spain
journal

Apoptotic tendency and genomic abnormalities of smooth muscle cells in thoracic aortic aneurysms
Acilan Ceyda, Gebze-Kocaeli, Turkey
journal

C-reactive protein (CRP) and aortic aneurysm:  real-time PCR analysis
Tozzi Matteo, Varese, Italy
journal

Apoptosis and elevation of Matrixmetalloproteinases in Ascending Aneurysms with a Bicuspid Aortic Valve
Mohamed Salaheldien Ali, Luebeck, Germany
journal

Expression of Matrix Metalloproteinase-2, -9 and Collagen I, III in Ascending Thoracic Aortic Aneurysms
Baysal Kemal, Gebze, Turkey
journal

Discovery of a novel circulating biomarker in patients with abdominal aortic aneurysm
Wallinder Jonas, Sundsvall, Sweden
journal



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PHYSIOPATHOLOGY OF AORTIC DISEASES
Moderators: Gillian Cockerill & Jean-Baptiste Michel

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14.30 Physiopathology of ascending aorta with bicuspid and tricuspid aortic valve
Alessandro Della Corte, Naples, Italy
pdf

14.45 Involvement of the intra luminal thrombus in aneurysmal acceleration towards rupture
Jean-Baptiste Michel, Paris, France
pdf

15.00 Blood tests for thoracic aortic aneurysm
John Elefteriades, New Haven, CT, USA
pdf

15.15 Novel biomarkers of AAA evolution
Jose Luis Martin-Ventura, Madrid, Spain

15.30 2 D electrophoresis based proteomic investigation of serum in AAA-patients
Sigitas Urbonavicius Viborg, Denmark

15.45 Molecular pathogenesis of AAA
Koichi Yoshimura, Ube, Japan
pdf

16.00 Short presentations

Impaired splicing of fibronectin is associated with thoracic aortic aneurysm formation in patients with bicuspid aortic valve
Paloschi Valentina, Stockholm, Sweden

Fibrin architecture is altered in abdominal aortic aneurysms and correlates with aneurysm size
Ariëns Robert A S, Leeds, United Kingdom

Uptake of 18-fluorodeoxyglucose (FDG) as detected by Positron Emission Tomography
(PET) is correlated to an increased expression of proteolytic enzymes in the wall of abdominal aortic aneurysms (AAA)
Courtois Audrey, Liège, Belgium
journal pdf


16.15 Discussion

16.30 Coffee break


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MANAGEMENT OF THORACIC AORTIC DISEASES
Moderators: John Elefteriades & Guido Van Nooten
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PART ONE - SESSION I
ASCENDING AORTA AND ARCH
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17.00 Place of the endovascular treatment in type A dissection
Stephan Haulon, Lille, France
pdf

17.15 EVAR in the aortic arch
Tilo Kölbel, Hamburg, Germany
pdf

17.30 Outcomes of the endovascular management of aortic arch aneurysm
Matthew Thompson, London, United Kingdom
pdf

17.45 Bovine aortic arch: not a benign variant
John Elefteriades, New Haven, CT, USA

pdf

18h00  Management of complicated type B dissection
Christoph Nienaber, Rostock, Germany
pdf

18.15 Discussion